Effect of calcium channel antagonists combined with exercise training on TNF and IL in rats with arthritis

  • Wang Yong
Keywords: Arthritis, Calcium Channel Antagonists, Exercise Training, Tumor Necrosis Factor, Interleukin


Athlete's joint injury is a kind of pathological change which often appears in the competitive sports
competition. It is inevitable that the joint injury appears in the intense competition or the long-term
high-intensity training. Osteoarthritis is a chronic joint disease characterized by the degeneration, destruction
and hyperosteogeny of articular cartilage. Athletes are one of the susceptible groups of osteoarthritis due to their
long-term overuse of joints. In recent years, it is suggested that there is an important relationship between
intracellular calcium and the activation and release of many inflammatory cells. In addition, the study found that
under a certain period of exercise training, the inflammatory response of the body can be properly alleviated and
the antioxidant capacity of the body can be improved. The levels of TNF-α, IL-4, IL-10 in serum, TNF-α, IL-6,
il-lp mRNA in cartilage and inflammatory joint were measured by enzyme linked immunosorbent assay (ELISA)
and reverse transcription polymerase chain reaction (RT-PCR), and the contents of SOD in skeletal muscle were
measured by xanthine oxidase. The results show that calcium channel antagonists and exercise training can
significantly reduce the injury of osteoarthritis and improve the antioxidant capacity of rats.