Effects of Ligustrazine on NO and Endothelin Levels in Rats with Experimental Myocardial Ischemia-reperfusion Injury

  • Shaohui Liu
Keywords: Ligustrazine Research, Experimental Myocardial Ischemia, Reperfusion Injury, Endothelin Level


Nitric oxide (no) and endothelin (ET) are two vasoactive substances secreted by vascular endothelial
cells. The aim of this paper is to study the effect of Ligustrazine on the levels of no and endothelin in rats with
experimental myocardial ischemia-reperfusion injury. In this paper, the changes of no and ET in plasma and
myocardial tissue were used to reflect the function of vascular endothelial cells, the activity of lactate
dehydrogenase (LDH) and the morphological changes of myocardial cells were used to reflect the degree of
myocardial damage, and Ligustrazine (LCT) was used to study the role of vascular endothelial cell dysfunction
in myocardial ischemia-reperfusion injury (MIRI) and the effect of LGT on it, To elucidate the mechanism of
LGT against MIRL and provide theoretical basis for strengthening the protection of heart during operation.
Linear correlation analysis showed that there was a significant negative correlation between the levels of NOP
and et before ischemia, 40 minutes after ischemia and 20 minutes after reperfusion, the correlation coefficients r
were - 0.601, - 0.751 and - 0.826, P values were > 0.05. < 0.05 and < 0.01, respectively, and the correlation
coefficients R were - 0.674 and - 0.804, P values were < 0.05 and < 0.01, respectively; however, there was a
significant positive correlation between ET and LDH at each time point. The correlation coefficient r was 0.695
and 0.794, respectively, P < 0.05 and P < 0.01.