The Role and Value of Submandibular Gland Ultrasonography in the Evaluation of Sjogren's Syndrome Animal Model

  • Hong Yue
Keywords: Submandibular Gland Ultrasonography, Sjogren's Syndrome, Animal Model

Abstract

To explore the effect of submandibular gland ultrasound imaging on the evaluation of Sjogren's
syndrome animal model, and analyze its role and value. 60 C57 mice were randomly selected as the normal
control group, and another 30 mice were randomly selected as the Sjogren's syndrome model on the 14th, 21st,
28th and 35th day. The saliva volume, drinking water volume and body weight of mice were measured, and the
submandibular gland index was measured. At the same time, the ultrasonic imaging system of small animals
was used to detect the area of submandibular gland and the change of blood flow signal of submandibular gland.
On the 14th, 21st, 28th and 35th day of modeling, the relative saliva quantity and relative drinking water
quantity of mice in the model group were detected respectively. Compared with the normal control group, the
relative saliva quantity of mice in the model group was significantly lower on the 28th and 35th day (P < 0.05),
while the relative drinking water quantity was significantly higher than that in the normal group (P < 0.05).
Compared with the normal control group, the index of submandibular gland in the model group increased on the
28th and 35th day of modeling, and it was statistically significant (P < 0.05). On the 28th and 35th day of the
model group, the axial area of submandibular gland was significantly higher than that of the normal group, and
the blood flow signal of submandibular gland was significantly higher than that of the normal group on the 28th
and 35th day (P < 0.05). Ultrasound imaging of submandibular gland can provide evidence and indicators for
the evaluation of Sjogren's syndrome animal model, and can provide a powerful tool for the evaluation of the
successful construction of Sjogren's syndrome model and the change of disease condition.

Published
2020-03-01