Protective Effect of Taurine on Diaphragm of Diabetic Rats

  • Jingying Qiu
Keywords: Taurine, Diabetic Rats, Diaphragm, Protective Effect


To explore the protective effect of taurine on diaphragm of diabetic rats and analyze its mechanism. A
total of 30 diabetic rats were randomly divided into two groups: model group and taurine group. The taurine
group was given 10g / L taurine solution every day for 4 weeks, and the model group was given clean drinking
water every day for 4 weeks. Four weeks later, the diaphragmatic tissues of the rats were sacrificed and
compared between the two groups in terms of the single systolic tension (PSC), the maximum tetanic tension
(Pmax), the systolic time (t contraction), the half diastolic time (T1 / 2 relaxation), the tension frequency curve
and the fatigue index (ifatigue); the blood glucose and the content of superoxide dismutase (SOD) and
malondialdehyde (MDA) in the diaphragm. Compared with the model group, the single systolic tension (PSC),
maximum tetanic tension (Pmax), tension frequency curve and fatigue index (ifatigue) of taurine group were
significantly higher, the systolic time (t-systolic) and the half diastolic time (T1 / 2 diastolic) were significantly
shorter, the difference was statistically significant (P < 0.05). Compared with the model group, the level of blood
glucose, superoxide dismutase (SOD) and malondialdehyde (MDA) in taurine group decreased significantly (P
< 0.05). Taurine can protect the state of diaphragm and improve the function of diaphragm by scavenging free
radicals, antioxidation and reducing blood sugar.