Effects of Different Exercises on Immune and Inflammatory Responses in Obese Rats
To explore the effects of three different modes of exercise on immune and inflammatory responses in obese rats. In this paper, high-fat diet-induced obese rats were subjected to 8-week high-intensity intermittent swimming training, continuous swimming training and weight-bearing ladder training. Three-week-old male SD rats were randomly divided into 4 groups: quiet. There were 10 control group (QC group), 10 high-intensity interval training group (HT group), 10 continuous training group (CS group) and 10 weight-bearing ladder training group (LC group). The expression rates of CD4+CD25+Treg and CD4+Foxp3+Treg cells in HT group were significantly higher than those in QC group (P<0.05). The expression rate of CD4+CD25+Treg cells was positively correlated with the expression rate of CD4+Foxp3+Treg cells (r=0.458, P<0.05). Compared with QC group, the levels of IL-10 and TNF-α in CS group and HT group were significantly lower (P<0.05). High-intensity interval training, continuous training and weight-bearing ladder training can effectively reduce the body weight of obese rats, and have different degrees of inhibition on spleen growth in obese rats. Among them, high-intensity interval training weight loss and inhibition of spleen growth are most obvious, weight-bearing ladder The training effect is the weakest. The effects of three kinds of exercise methods on the body immunity of obese rats are as follows: high-intensity interval training helps the body maintain immune homeostasis, and continuous training has no obvious promotion or inhibition on body immunity. Weight-bearing ladder training has a certain degree of immunity to the body. Inhibition. The effect on the inflammatory response is as follows: high-intensity interval training and continuous training reduce the expression of TNF-α and IL-10, and the effect on the inflammatory response needs further study, while the weight-bearing ladder training has a certain degree of inhibition on the inflammatory response.