Effects of Different Exercises on Immune and Inflammatory Responses in Obese Rats

  • Xiao Ma


To explore the effects of three different modes of exercise on immune and inflammatory responses in obese rats. In this paper, high-fat diet-induced obese rats were subjected to 8-week high-intensity intermittent swimming training, continuous swimming training and weight-bearing ladder training. Three-week-old male SD rats were randomly divided into 4 groups: quiet. There were 10 control group (QC group), 10 high-intensity interval training group (HT group), 10 continuous training group (CS group) and 10 weight-bearing ladder training group (LC group). The expression rates of CD4+CD25+Treg and CD4+Foxp3+Treg cells in HT group were significantly higher than those in QC group (P<0.05). The expression rate of CD4+CD25+Treg cells was positively correlated with the expression rate of CD4+Foxp3+Treg cells (r=0.458, P<0.05). Compared with QC group, the levels of IL-10 and TNF-α in CS group and HT group were significantly lower (P<0.05). High-intensity interval training, continuous training and weight-bearing ladder training can effectively reduce the body weight of obese rats, and have different degrees of inhibition on spleen growth in obese rats. Among them, high-intensity interval training weight loss and inhibition of spleen growth are most obvious, weight-bearing ladder The training effect is the weakest. The effects of three kinds of exercise methods on the body immunity of obese rats are as follows: high-intensity interval training helps the body maintain immune homeostasis, and continuous training has no obvious promotion or inhibition on body immunity. Weight-bearing ladder training has a certain degree of immunity to the body. Inhibition. The effect on the inflammatory response is as follows: high-intensity interval training and continuous training reduce the expression of TNF-α and IL-10, and the effect on the inflammatory response needs further study, while the weight-bearing ladder training has a certain degree of inhibition on the inflammatory response.