Rare Earth Upconversion Luminescent Nanomaterials for Lymphatic Imaging in Small Animals

  • Qin Zhang
Keywords: Rare Earth Upconversion, Luminescent Nanomaterials, Small Animal Lymphatic System


Lymphography is a hot issue in oncology, the accurate location of sentinel lymph nodes can provide
guidance for the diagnosis and treatment of tumors. Fluorescence imaging is the only way to visualize cells and
small animals in vivo. A key problem in this field is how to further improve the penetration depth and
signal-to-noise ratio. Rare earth nanomaterials are rich in optical, magnetic, X-ray absorption and radioactive
energy, are a kind of important multi-functional materials. In order to apply them to biomedical imaging and
biological detection, people need to develop new rare earth nanomaterials. Integrating its special properties, it
can be used in multi-mode imaging and biological detection. This paper aims to explore the application of rare
earth upconversion luminescent nanomaterials in lymph node imaging of small animals. Rare earth
upconversion luminescent nanomaterials were used in many small animal models, such as mice and rabbits.
Up-conversion luminescence in vivo lymphography of shallow cervical, deep cervical and axillary multilocus
lymph nodes was realized. Using different polymers as synergistic ligands, rare earth upconversion luminescent
nanomaterials labeled with radioactivity and less than 10 nm were synthesized directly, the distribution of rare
earth nanomaterials coated with different polymers in vivo was observed by SPECT imaging. The results show
that rare earth is a conversion luminescent nanomaterial (CUNPs) with high lymphatic tropism and high
signal-to-noise ratio. In addition, we found that water-soluble nanomaterials with a wide range of sizes can be
used for lymph node imaging; however, the matrix and surface coating of CUNPs had no significant effect on
lymphatic imaging.