Accumulation and Metabolism of Fluoride from Antarctic Krill (Euphausia Superba) in Rats

  • Lanlan Zhu
Keywords: Antarctic Krill, Fluoride, Accumulation, Toxicity, Rats

Abstract

Fluorine is an essential element for living organisms, but it also needs to be limited in intake. The
occurrence form of fluorine has a significant effect on its toxicity. The occurrence form of fluorine in Antarctic
krill is complex, and its toxicity can not be simply equal to that of normal food. A view of its broad application
prospects in food, it is necessary to evaluate the acute and chronic toxicity of fluoride in Antarctic krill from the
perspective of accumulation and metabolism. In acute toxicity test, the maximum dosage of Antarctic krill powder
was 20g/kg Bw, and the oral lethal dose of Antarctic krill powder was LD50 > 20g/kg Bw. Fluoride in Antarctic
krill meal had no significant effect on the lipid metabolism related indicators of the tested animals, but it could
cause oxidative stress reaction in the tested animals and reduce the antioxidant capacity of the body; and it could
cause potential kidney damage and clear liver damage through oxidative stress reaction. Fluoride in Antarctic
phosphatide powder accumulated significantly in bone and teeth, but the degree of fluoride accumulation was
significantly weaker than that of sodium fluoride; in organs vulnerable to oxidative stress, fluoride in Antarctic
krill only showed slight accumulation in lungs, similar to that in sodium fluoride level, but not significant; fluoride
and sodium fluoride in Antarctic krill accumulated slightly in other soft tissues such as brain, spleen, heart and
brain. No accumulation was found in testes and ovaries of reproductive organs.

Published
2019-09-01