Protective Effect of DMSA on Reproductive System Damage in Lead Infected Male Mice

  • Yilin Ding
Keywords: Lead Acetate, Lead Poisoning, Reproductive System Damage, Mouse Research

Abstract

Lead poisoning has attracted more and more attention. In order to avoid the systemic damage caused
by lead to humans or animals, this study aims to study whether DMSA has a protective effect on the
reproductive system damage of male mice stained with lead. Lead poisoning mouse models were made from
healthy adult (9-week-old) clean grade kunming white mice infected with lead acetate and treated with different
amounts of DMSA. Body weight, testicular visceral coefficient, serum FSH and testosterone concentrations, and
morphological changes in testicular tissue were observed before and after treatment. The results showed that
compared with the control group, there was no significant change in testicular organ coefficient in the model
group (P>0.05), and serum FSH and T levels decreased (P<0.01). After different doses of DMSA, all indicators
(40mg/kg DMSA) in the treatment group 1 showed no significant change compared with the model group
(P>0.05). In the treatment group 2(80mg/kg DMSA), there was no significant change in testicular organ
coefficient (P>0.05). Serum T level was increased, and the difference was statistically significant (P<0.01).
There was no significant change in serum FSH concentration (P>0.05). There was no significant change in
testicular organ coefficient (P>0.05), and serum FSH and T levels were increased (P<0.01 or P<0.05) in the 3
treatment groups (120mg/kg DMSA).DMSA protected the reproductive system of lead-infected male mice.

Published
2019-11-01