Guinea Pigs with Polycystic Ovary Syndrome Induced by Letrozole

  • Jiakai Sun
Keywords: Letrozole, Polycystic Ovary Syndrome, Gguinea Pig, Animal Model, Drug Research

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disease period of women of childbearing
age, its incidence in women of childbearing age is 5% -10%, the pathogenesis is not yet clear. Currently, animal
models are mostly used to study the etiology, pathogenesis, clinical diagnosis and treatment strategy of PCOS.
In this study, we investigated the changes of serum hormone levels and body mass in 3-month old female guinea
pig model of poly-cystic ovary syndrome (PCOS) induced by Letrozole. Abstract: in this paper, the guinea pigs
with pcos were established by using Letrozole gavage method, and the changes of serum Testosterone (T),
luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined by radioimmunoassay, and
compared with the control group. Weight of guinea pigs was continuously measured and weight gain of each
guinea pig was calculated and compared with the control group. It was found that the serum T level in the
experimental group was significantly higher than that in the control group (P <0.05). The increase in body mass

of guinea pigs in the experimental group was significantly higher than that in the control group (P <0.05). The
experimental results showed that the effects of letrozole on serum sex hormone and body mass of guinea pig
PCOS model were close to the clinical manifestations, which met the requirements of animal PCOS modeling.

Published
2019-11-01