Effects of Over Swimming Training on Immune Regulation Mechanism in Mice

  • Xiaoxiao Huang
Keywords: Swimming, Immunity, Overtraining, Regulatory Mechanism


The aim is to explore the system of high intensity exercise training affecting the changes of body
immune system by establishing a mouse model. By studying the effect of high intensity swimming training on
the immune regulation ability of mice, in this study, the factors that can cause excessive high intensity exercise
to have a negative impact on the immune regulation ability of the organism are explored, so as to avoid
unnecessary diseases caused by athletes during high intensity training. Thirty-six male mice are divided into
three groups: control group, exhaustion group and 50-minute swimming group. The first index is the behavioral
status of mice, spleen index, and weight loss and increase, the second index is the immune cells in the immune
system of mice, the third index is the change of testosterone hormone, and the fourth index is the expression of
receptors and genes. Through these indicators, the effect of excessive swimming training on the immune
regulation mechanism of mice has been studied. The results show that high-intensity and high-load swimming
training can make the hair of mice dry, chaotic and sparse, reduce reaction ability, diet and weight, decrease the
number of immune cells in the immune system and testosterone hormone levels. Therefore, it can be inferred
that high-load training can cause the decline of immune system regulation ability in mice. The decrease may be
due to the decrease of TLR4 receptor and transcription factor NF-κB in TLR4-NF-κB signaling pathway.