Therapeutic Mechanism of Aerobic Exercise on Hepatic Fibrosis in Mice with Obstructive Jaundice

  • Shumei Liu
Keywords: Aerobic Exercise, Obstructive Jaundice, Liver Fibrosis, LincRNA-p21

Abstract

Hepatic fibrosis is a pathological process characterized by the proliferation of extracellular matrix
after liver injury. Liver fibrosis can develop into cirrhosis, which is the most common non-neoplastic cause of
death in digestive diseases. Its morbidity and mortality are increasing year by year, seriously threatening human
health. The aim of this study is to establish obstructive jaundice model mice, to explore the feasibility of aerobic
exercise in treating hepatic fibrosis in mice with obstructive jaundice. By observing and studying the behavior of
mice and the expression of liver tissue, the detection of liver fibrous index, the change of hepatic glycogen and
the pathological study of liver tissue, etc. It can be concluded that long-term regular aerobic exercise can
intervene in mice with obstructive jaundice and improve the immune function of mice with liver injury. It can
repair hepatocytes of mice with obstructive jaundice and improve liver fibrosis. At the same time, it can alleviate
the symptoms of liver fibrosis or cirrhosis caused by non-alcoholic fatty liver, hepatitis and liver cancer. Aerobic
exercise can promote the expression of LincRNA-p21 and inhibit Notch pathway to improve liver injury. The
comparative model group is obtained by the experimental method in this paper, there was a significant
difference in the expression of LincRNA-p21 in liver tissue between aerobic exercise group and control group
(P < 0.01).

Published
2019-11-01