Effects of Aerobic Exercise on Skeletal Muscle Oxidative Stress and GRP78, CHOP in Rats

  • Yi Zhou
Keywords: Aerobic Exercise, Oxidative Stress, Endoplasmic Reticulum Stress, Skeletal Muscle

Abstract

In the process of exercises, a large number of free radicals produced and accumulated will lead to
sports fatigue or sports injury, intake of antioxidants can effectively increase antioxidant capacity. At present,
there is no effective guidance and Research on reasonable supplementation of antioxidants during and after
exercise. The aim of this study was to investigate the effects of long-term aerobic exercise, one exhaustive
exercise, aerobic exercise combined with one exhaustive exercise on oxidative stress level of soleus muscle and
endoplasmic reticulum stress of skeletal muscle in rats. To explore the relationship between soleus muscle
oxidative stress and endoplasmic reticulum stress in three different exercise modes through the changes of
soleus muscle oxidative stress and endoplasmic reticulum stress in rats, in order to study the molecular
mechanism of soleus muscle oxidative stress and endoplasmic reticulum stress induced by exercise, the
theoretical basis of preventing exercise and the treatment of diseases related to oxidative stress and endoplasmic
reticulum stress. The results show that: Endoplasmic reticulum stress index GRP78 was negatively correlated
with oxidative stress index SOD (r = 0.55, P < 0.05), MDA and CAT were negatively correlated with oxidative
stress (r = 0.44, P < 0.05), while other indicators were not significantly correlated.

Published
2019-11-01