Aerobic Exercise and High-fat Diet on Lipid Metabolism in Mice and the Effects of Endoplasmic Reticulum Stress

  • Cong Ding
Keywords: Aerobic Exercise, High Fat Diet, Lipid Metabolism, Endoplasmic Reticulum Stress

Abstract

Unhealthy diets and lifestyles cause obesity, dyslipidemia and other diseases. The purpose of this
paper is to explore the effects of aerobic exercise and high-fat diet on blood lipid metabolism and liver tissue
endoplasmic reticulum stress in mice through aerobic exercise and high-fat diet intervention. This experiment
selects 40 adult male Kunming adults. The mice were randomly divided into 4 groups: normal diet control group
(group C), high fat diet group (group H), aerobic exercise group (group A), aerobic exercise high fat diet group
(AH group), 10 rats in each group were given diet and exercise intervention. Groups H and AH were fed a highfat
diet. Group A and AH were given five-day treadmill training every week for 60 minutes for 8 weeks. All
mice were weighed once a week. At the end of the experiment, serum triglyceride (TG), total cholesterol (TC)
and high-density lipoprotein (HDL-C) levels were measured, and glucoprotein 78 (GRP18) in liver tissue was
detected. The comparison was carried out before and after the experiment. After experiment, the body weight of
group H increased significantly after 8 weeks of experiment, the difference was significant (p<0.05); the TG
content of group H and AH group decreased significantly, the difference was very significant (p<0.01); The TC
content in the AH group was significantly increased, and the difference was significant (p<0.05). The TC
content in the A group was significantly decreased, and the difference was significant (p<0.05). The HDL-C
content in the H group was significantly decreased, and the difference was significant (p < 0.05), the level of
GRP78 in group H was significantly increased, and the level of GRP78 in group AH was increased, but
significantly lower than that in group H. It can be concluded that aerobic exercise can improve the lipid
metabolism disorder in mice caused by high-fat diet and reduce the endoplasmic reticulum stress level in mice
with high-fat diet.

Published
2019-11-01