Effects of Aerobic Exercise and Resistance Exercise on Cardiac Function in Rats with Heart Failure

  • Shiyan Jiang
Keywords: Aerobic Exercise, Resistance Exercise, Heart Failure, N-terminal Pro-Brain Natriuretic Peptide, Cardiac Index


Among the causes of death worldwide, cardiovascular disease is one of the most important causes of
death, and the severe aging of the population is one of the leading causes of the increasing number of
cardiovascular patients. With the aging of China's population, the incidence of hypertension and coronary heart
disease has increased year by year, making the prevention and treatment of heart failure more severe. Therefore,
the high incidence of heart failure and high mortality have become a global problem. Based on the above
background, the purpose of this paper is to observe the effects of aerobic exercise and resistance exercise on
cardiac function in rats with heart failure. In this paper, 60 SD rats were randomly selected as the control group,
and the remaining 52 were injected with isoproterenol subcutaneously to establish a heart failure model. After
successful modeling, the model survival rats were randomly divided into model group, aerobic exercise group,
anti-resistance exercise group and aerobic exercise combined resistance exercise group, with 12 rats in each
group. Each group was tested for NT-pmBNP by Elisa after 8 weeks according to different exercise regimens,
and the HMI index of the rats was calculated. The HMI index of the control group, the model group, the aerobic
exercise group, the resistance exercise group, and the aerobic exercise combined resistance exercise group were
(2.44±0.23) mg/g, (3.53±0.21) mg/g, (3.11±0.23) mg/g, (3.07±0.20) mg/g, (2.86±0.15) mg/g, NT-pmBNP index
was (96.39±18.76) pg/mL, (445.65±34.17) pg/mL, (341.22 ±23-23)pg/mL, (333.82±17.64) pg/mL,
(290.68±14.99) pg/mL; aerobic exercise group, resistance exercise group, aerobic exercise combined resistance
exercise group can significantly reduce heart. The NT-pmBNP and HMI index of the aging rats were
statistically significant compared with the model group (P<0.01). Compared with the aerobic exercise group and
the resistance exercise group, the aerobic exercise combined with the resistance exercise group was more
effective.But there was no significant difference between the aerobic exercise group and the resistance exercise
group (P>0.05). The study found that aerobic exercise and resistance exercise can improve heart failure, and the
effect of aerobic exercise combined with resistance exercise to improve heart failure is more significant.