Swimming Increases the Level of Myocardial Autophagy in Spontaneously Hypertensive Rats

  • Chunjin Jiang
Keywords: Aerobic Exercise, Spontaneous Hypertension, Myocardial Structure, Autophagy Level


With the rapid development of China's economy, China's Engel coefficient has declined year by year.
However, due to changes in dietary structure, the incidence of hypertension in China has increased year by year
in recent years, and it has become smaller and smaller in age. Because high blood pressure can lead to a decline
in the body function of patients, which seriously affects their quality of life, which makes the prevention and
treatment of hypertension become urgent. The purpose of this paper is to investigate the improvement in
swimming motility and the improvement of myocardial basal autophagy in spontaneously hypertensive rats. In
this paper, the rat heart function test and autophagy markers were used to test the exercise group and the quiet
group. The experimental results showed that the left ventricular end-diastolic pressure of the rats after
swimming (P<0.01), left ventricular end-systolic pressure (P<0.05). It can be seen that long-term aerobic
exercise may improve the myocardial structure and function of hypertensive rats by promoting the conversion of
LC-I to LC3-II and the degradation of P62 and the increase of Beclin1.