Swimming Can Inhibit the Abnormal Coagulation Function of HCFD Induced Obese Rats

  • Guilan Xu
Keywords: High Carbohydrate and Fat Diet, Abnormal Blood coagulation, Obese Rats, Inflammatory Markers


The incidence of overweight and obesity is increasing, which seriously affects the onset and progress
of related diseases. The potential harm restricts the improvement of national physical fitness and health level,
and brings heavy economic burden and mental burden to families and society. Obesity is a chronic disease state,
which has been prevalent in the world, and obesity can cause or aggravate a series of common chronic diseases.
Based on the above background, the purpose of this paper is to study the inhibition of HCFD-induced
coagulation dysfunction in obese rat models. In this paper, 40 male Wistar rats were randomly divided into 4
groups: control group, control + swimming group, HCFD group and HCFD+ swimming group. Rats in each
group were fed for 15 weeks, in which the control rats were fed with standard laboratory feed for 15 weeks; the
HCFD group was fed with HCFD for 15 weeks. Swimming rats were trained to swim from week 11 to week 15.
Then, the inflammatory markers and coagulation related indexes of the rats in each group were detected. Results
HCFD caused a significant increase in blood glucose, IR, dyslipidemia and inflammatory biomarkers in rats. In
addition, HCFD significantly increased coagulation and thrombosis biomarkers in rats, such as fibrinogen,
plasminogen activator inhibitor-1, prothrombin time, activated partial thromboplastin time, coagulation and
bleeding time, and platelet aggregation. Etc., while swimming can inhibit the increase of the above indicators in
HCFD rats, especially the IL-6 index, which decreased from 679.85pg/ml to 189.75pg/ml. It can be seen that in
the obese and IR rat models, coagulation dysfunction can be improved by swimming.